Praziquantel target validation of a Ca2+ permeable channel in schistosomes

Donna Huber on January 18, 2023

Six rows of circular markers labeled S1, S4, and TRP display combinations of letters and colors, categorized as Sensitive, Insensitive, or Highly Sensitive for target validation in praziquantel-treated schistosomes.

Six rows of circular markers labeled S1, S4, and TRP display combinations of letters and colors, categorized as Sensitive, Insensitive, or Highly Sensitive for target validation in praziquantel-treated schistosomes.Highlights

  • Schistosomiasis is a devastating neglected helminthic disease.
  • Praziquantel (PZQ) is the most important drug against schistosomiasis.
  • Previous work identified a TRP channel of the melastatin type as a PZQ target.
  • Molecular studies now reveal the basis for varied PZQ sensitivity of different helminths.

Roberto Docampo. Cell Calcium. 2023 Jan 18;110:102698. doi: 10.1016/j.ceca.2023.102698