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Author: Donna Huber

Identification of an Orally Efficacious Imidazo[4,5- c]pyridine-6-Carboxamide Antimalarial with a High Barrier to Resistance

Donna Huber on April 27, 2026

Due to the emergence of resistance to both artemisinin derivatives, and their partner drugs, new antimalarials are urgently needed. Ideally, new orally active antimalarials would not only engage new targets but also demonstrate a high barrier to resistance selection, and the ability to kill both proliferating rings and growth-arrested rings resulting from artemisinin exposure. In …

Vaccine elicitation of HIV broadly neutralizing antibodies from genome-edited B cells in non-human primates and derived lymphoid organoids

Donna Huber on April 10, 2026

HIV broadly neutralizing antibodies (bnAbs) are promising reagents for prevention and therapy of disease; however, their elicitation is constrained by genetic limitations of the human B cell antigen-receptor (BCR) repertoire. Precision genome-editing offers a potential solution by enabling bnAb genes to be programmed into the BCR repertoire as IgH-modified B cells. Such cells can be …

Glycosomal Phosphoenolpyruvate Carboxykinase CRISPR/Cas9-Deletion and Its Role in Trypanosoma cruzi Metacyclogenesis and Infectivity in Mammalian Host

Donna Huber on March 12, 2026

Trypanosoma cruzi, the causative agent of Chagas disease, possesses glycosomes-unique organelles that house key metabolic enzymes, several of which are promising therapeutic targets. Among them, phosphoenolpyruvate carboxykinase (PEPCK) plays a central role in succinic fermentation, the main pathway for NAD+ regeneration within the organelle. Using CRISPR/Cas9 editing, the PEPCK gene was disrupted in T. cruzi, …

Integrated Approaches to Surveillance of Lymphatic Filariasis and Other Infectious Diseases in the Pacific Islands

Donna Huber on February 27, 2026

Lymphatic filariasis (LF) is a mosquito-borne neglected tropical disease targeted by the World Health Organization (WHO) for global elimination as a public health problem. Sixteen Pacific Island countries and territories were historically endemic, and eight have now met the WHO criteria for elimination as a public health problem. Elimination as a public health problem does …

In the News: Sam Kurup

Donna Huber on February 27, 2026

Dr. Sam Kurup started his career at UGA as a graduate student, and now he is an associate professor in the Department of Cellular Biology. Learn more about his journey from mentee to mentor in this Red & Black article.

No effector is an island: joint action of Toxoplasma gondii secreted effectors in host immune subversion

Donna Huber on February 16, 2026

Combinatorial suppression of IFN-γ signaling by T. gondii nuclear effectors.   The molecular dialogue between host and pathogen is defined by competition for the intracellular niche. Toxoplasma gondii exemplifies this mastery by deploying secreted effectors to remodel host cell biology and neutralize immune defenses. Yet a striking paradox has emerged, in which, despite exporting only …

Progress Toward Eradication of Dracunculiasis (Guinea Worm Disease) – Worldwide, January 2024-June 2025

Donna Huber on January 1, 2026

Dracunculiasis (Guinea worm disease), caused by the parasite Dracunculus medinensis, is acquired by drinking water containing small water fleas infected with D. medinensis larvae or eating inadequately cooked aquatic animals. Efforts to eradicate D. medinensis, including the Guinea Worm Eradication Program (GWEP), began at CDC in 1980. In 1986, with an estimated 3.5 million cases …