Note: Application for open positions must be made through the Human Resources website. Please click the apply button below the position description to be taken directly to the posting on the Human Resources website.
Postdoctoral Scientist (Posting # G/R22870P)
Research Tech I (Posting # S09866P)
The Rosenberg Research Group has an opening for a Research Technician. This person will assist in daily operations of the lab. This includes the maintenance of tissue culture facilities, ordering, and organization of laboratory materials
Lab Manager (Posting # S09094P)
The Rosenberg laboratory has an opening for a Lab Manager. This person, in addition to carrying out experimental procedures, will be in charge of daily operations of the lab. This includes the maintenance of tissue culture facilities, ordering and organization of laboratory materials, and more generally supporting a positive laboratory environment and facilitating the carrying out of experiments by laboratory personnel.
Postdoctoral Associate (Posting #G/R20167P)
These post-docs will be part of the laboratory of Silvia Moreno to study Calcium Signaling in Toxoplasma gondii. The projects involve characterization of the role of specific calcium signaling proteins in the biology of T. gondii, and their expression and further physiological characterization using heterologous systems. These projects entail collaborations and training by Calcium channel experts and global analysis of calcium-triggered signaling networks.
Ca2+ signaling regulates pathogenicity of apicomplexan parasites, which cause persistent mortality and morbidity worldwide through diseases including malaria, toxoplasmosis, and cryptosporidiosis. The phylum member Toxoplasma gondii infects >2 billion people worldwide. T. gondii is an obligate intracellular parasite whose replication and dissemination within its host are the main mechanisms by which it causes disease. Ca2+ signaling is central to T. gondii’s ability to complete its infection cycle and thus its resulting pathology. However, many of the molecular elements of the initial Ca2+ signals in T. gondii are unknown or uncharacterized. We seek to discover these molecules, specifically, the channels that enable cytosolic Ca2+ influx, through the plasma and intracellular stores membranes. There is very little information about the functional characteristics and roles of Ca2+ channels in T. gondii. Channels are critical for the successful unicellular life of parasites, and they could be targeted by many therapeutically useful agents.
Recent references from the lab:
• Márquez-Nogueras, K.M., Chasen, N. M. Hortua Triana, M.A., Kuo, I. Y. Moreno, S.N.J. (2021). Calcium signaling through a Transient Receptor Channel is important for Toxoplasma gondii growth. Elife, 10:e63417.
A comment about this work was published: TRP channels, the missing link for Ca 2+ tuning by a unicellular eukaryotic parasite?, Theopold U. and Barragan, A. Cell Calcium, 2021 98:102449
• Li, Z.H., King, T., Ayong, L. Vella, S. Chasen, N., Patel, S. Moreno, S.N.J. (2021). A plastid Two-Pore Channel that is relevant for organelle integrity and whole cell fitness. Nat. Commun. 12(1):5802.
A comment about this work was published: Ca2+ Signalling is a Conserved Game of Contact (2022). Casbolt, H. and Campanella, M. SAGE Journals Vol 5. Article Commentary. https://doi.org/10.1177/25152564221095961
• Vella, S.A., Moore, C.A., Li, Z., Hortua Triana, M.A., Potapenko, E. Moreno, S.N.J. (2021). The Role of Potassium and Host Calcium Signaling in Toxoplasma gondii Egress. Cell Calcium, 94:102337
• Herneisen, A.L., Li, Z.H., Chan, A.W., Moreno, S.N.J., Lourido, S. (2022) De novo mapping of the apicomplexan Ca2+-responsive proteome. Elife 11: e80336. doi: 10.7554/eLife.80336.
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