Microbial virulence often relies on secreted effectors that modulate host signal transduction, the revelation of the functional mechanisms of pathogen effectors not only leads to a better understanding of microbial virulence strategies but also has the potential to impact human health through novel treatment strategies. Over the past decades, extensive studies of viral and bacterial virulence have immensely expanded our knowledge and understanding of host-pathogen interaction. However, viruses and bacteria are only two classes of microbes that can cause disease, and surprisingly little is known about how eukaryotic pathogens manipulate their hosts. In our lab, we use Toxoplasma gondii as a model organism to study the sophisticated mechanisms this pervasive human eukaryotic pathogen uses to modulate the host immune system.
List of relevant publications
Rosenberg A, Sibley LD. Epigenetic Modifiers Alter Host Cell Transcription to Promote Toxoplasma Infection. ACS Infect Dis. 2022 Feb 24. doi: 10.1021/acsinfecdis.2c00054. PMID: 35201740
Rosenberg A, Sibley LD. Toxoplasma gondii secreted effectors co-opt host repressor complexes to inhibit necroptosis. Cell Host & Microbe. 2021 May 20: DOI: 10.1016/j.chom.2021.04.016. PMID: 34043960
Rosenberg A, Luth MR, Winzeler EA, Behnke M, Sibley LD. Evolution of resistance in vitro reveals mechanisms of artemisinin activity in Toxoplasma gondii. Proc Natl Acad Sci U S A. 2019 Dec 5;116(52):26881-91. PMID: 31806760