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Author: Donna Huber

Affinity‐based proteomics reveals novel targets of inositol pyrophosphate (5‐IP7)‐dependent phosphorylation and binding in Trypanosoma cruzi replicative stages

Donna Huber on December 22, 2020

Diphosphoinositol-5-pentakisphosphate (5-PP-IP5 ), also known as inositol heptakisphosphate (5-IP7 ), has been described as a high-energy phosphate metabolite that participates in the regulation of multiple cellular processes through protein binding or serine pyrophosphorylation, a post-translational modification involving a β-phosphoryl transfer. In this study, utilizing an immobilized 5-IP7 affinity reagent, we performed pull-down experiments coupled with mass spectrometry identification, …

Evolution of the monitoring and evaluation strategies to support the World Health Organization’s Global Programme to Eliminate Lymphatic Filariasis

Donna Huber on December 22, 2020

The Global Programme to Eliminate Lymphatic Filariasis (GPELF) was established with the ambitious goal of eliminating LF as a public health problem. The remarkable success of the GPELF over the past 2 decades in carrying out its principal strategy of scaling up and scaling down mass drug administration has relied first on the development of …

Fall 2020 Newsletter

Donna Huber on December 11, 2020

Learn about our research activities, faculty honors, new grants, and trainees from the summer and fall. [button size='large' style='' text='Read Now' icon='' icon_color='BA0C2F' link='http://ctegd.uga.edu/docs/ctegd/newsletter_Dec_2020_video.pdf' target='_self' color='' hover_color='' border_color='' hover_border_color='' background_color='' hover_background_color='' font_style='' font_weight='' text_align='center' margin='']

Different Sensitivity of Control and MICU1- and MICU2-Ablated Trypanosoma cruzi Mitochondrial Calcium Uniporter Complex to Ruthenium-Based Inhibitors

Donna Huber on December 7, 2020

The mitochondrial Ca2+ uptake in trypanosomatids shares biochemical characteristics with that of animals. However, the composition of the mitochondrial Ca2+ uniporter complex (MCUC) in these parasites is quite peculiar, suggesting lineage-specific adaptations. In this work, we compared the inhibitory activity of ruthenium red (RuRed) and Ru360, the most commonly used MCUC inhibitors, with that of the recently …

Rick Tarleton elected AAAS Fellow

Donna Huber on November 30, 2020

Photo credit: Andrew Tucker University of Georgia researcher Rick Tarleton has been elected as a 2020 American Association for the Advancement of Science (AAAS) Fellow by the AAAS Council “for distinguished contributions to the field of biological sciences, particularly for his research contributions and leadership to control Chagas Disease.” Tarleton is a Regents Professor in …

Jessica Kissinger elected ASTMH Fellow

Donna Huber on November 16, 2020

Jessica Kissinger (Photo by Peter Frey) University of Georgia geneticist Jessica Kissinger has been elected a 2020 American Society of Tropical Medicine and Hygiene Fellow. Kissinger is a Distinguished Research Professor in the Department of Genetics, part of the Franklin College of Arts and Sciences. She also holds appointments in the Institute of Bioinformatics and Center for Tropical and Emerging Global Diseases. …

Towards a comprehensive research and development plan to support the control, elimination and eradication of neglected tropical diseases

Donna Huber on November 11, 2020

To maximise the likelihood of success, global health programmes need repeated, honest appraisal of their own weaknesses, with research undertaken to address any identified gaps. There is still much to be learned to optimise work against neglected tropical diseases. To facilitate that learning, a comprehensive research and development plan is required. Here, we discuss how …

The nucleocytosolic O-fucosyltransferase Spindly affects protein expression and virulence in Toxoplasma gondii

Donna Huber on November 9, 2020

Once considered unusual, nucleocytoplasmic glycosylation is now recognized as a conserved feature of eukaryotes. While in animals O-GlcNAc transferase (OGT) modifies thousands of intracellular proteins, the human pathogen Toxoplasma gondii transfers a different sugar, fucose, to proteins involved in transcription, mRNA processing and signaling. Knockout experiments showed that TgSPY, an ortholog of plant SPINDLY and paralog of host OGT, …