Author: Donna Huber

Toxoplasma gondii

A terminal α3-galactose modification regulates an E3 ubiquitin ligase subunit in Toxoplasma gondii

[vc_row css_animation="" row_type="row" use_row_as_full_screen_section="no" type="full_width" angled_section="no" text_align="left" background_image_as_pattern="without_pattern"][vc_column width="2/3"][vc_column_text]Skp1, a subunit of E3 Skp1/Cullin-1/F-box protein ubiquitin ligases, is modified by a prolyl hydroxylase that mediates O2-regulation of the social amoeba Dictyostelium and the parasite Toxoplasma gondii. The full effect of hydroxylation requires modification of the hydroxyproline by a pentasaccharide...

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Antimalarial Diterpenoids From Vitex Rotundifolia: Isolation, Structure Elucidation, and in Vitro Antiplasmodial Activity

[vc_row css_animation="" row_type="row" use_row_as_full_screen_section="no" type="full_width" angled_section="no" text_align="left" background_image_as_pattern="without_pattern"][vc_column width="2/3"][vc_column_text] Vitex rotundifolia is an important medicinal plant frequently employed in traditional medicines for the treatment of various ailments. Although this plant species has been under exploration for its constituents by various research groups including our own group,...

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Supplemental Articles: Operational Research on Controlling and Eliminating Schistosomiasis (SCORE)

[vc_row css_animation="" row_type="row" use_row_as_full_screen_section="no" type="full_width" angled_section="no" text_align="left" background_image_as_pattern="without_pattern"][vc_column width="2/3"][vc_column_text] These articles are available online ahead of print and summarize much of the work of the Schistosomiasis Consortium for Operational Research and Evaluation (SCORE). The articles will be published as a supplement to the July issue of...

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Directing Traffic: Chaperone-mediated protein transport in malaria parasites

[vc_row css_animation="" row_type="row" use_row_as_full_screen_section="no" type="full_width" angled_section="no" text_align="left" background_image_as_pattern="without_pattern"][vc_column width="2/3"][vc_column_text]The ability of eukaryotic parasites from the phylum Apicomplexa to cause devastating diseases is predicated upon their ability to maintain faithful and precise protein trafficking mechanisms. Their parasitic life cycle depends on the trafficking of effector proteins...

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Cyclospora

Ynes Ortega receives grant to study Cyclospora presence in the U.S.

[vc_row css_animation="" row_type="row" use_row_as_full_screen_section="no" type="full_width" angled_section="no" text_align="left" background_image_as_pattern="without_pattern"][vc_column width="2/3"][vc_column_text] Historically, Cyclospora infection in the United States has been associated with imported fresh produce. However, in 2018, the U.S. saw two significant outbreaks associated with vegetables grown in the United States. “We had more than 2,000 non-travel associates...

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Roberto Docampo

UGA researchers join team of 100+ scientists to develop genetic tools for marine protists

[vc_row css_animation="" row_type="row" use_row_as_full_screen_section="no" type="full_width" angled_section="no" text_align="left" background_image_as_pattern="without_pattern"][vc_column width="2/3"][vc_column_text] [caption id="attachment_5794" align="aligncenter" width="600"] Docampo is Barbara and Sanford Orkin/GRA Eminent Scholar in Emerging Diseases and Cellular Biology and professor in the Franklin College of Arts and Sciences. (Photo by Billy Howard)[/caption] Roberto Docampo and colleagues at the...

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Dan Colley

Global Schistosomiasis Alliance pays tribute to Dan Colley

[vc_row css_animation="" row_type="row" use_row_as_full_screen_section="no" type="full_width" angled_section="no" text_align="left" background_image_as_pattern="without_pattern"][vc_column width="2/3"][vc_column_text] [caption id="attachment_4108" align="alignnone" width="600"] Dan Colley in his lab at UGA (photo credit: Andrew Tucker)[/caption]   Dr. Daniel G. Colley, Director of the Schistosomiasis Consortium for Operational Research and Evaluation (SCORE), will be retiring from his position as Professor...

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Design, Synthesis, and Evaluation of Novel Anti-Trypanosomal Compounds

[vc_row css_animation="" row_type="row" use_row_as_full_screen_section="no" type="full_width" angled_section="no" text_align="left" background_image_as_pattern="without_pattern"][vc_column width="2/3"][vc_column_text] Human African trypanosomiasis (HAT) is a deadly neglected tropical disease caused by the protozoan parasite Trypanosoma brucei. During the course of screening a collection of diverse nitrogenous heterocycles, we discovered two novel compounds that contain the tetracyclic core...

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Noelia Lander

Noelia Lander receives research award

[vc_row css_animation="" row_type="row" use_row_as_full_screen_section="no" type="full_width" angled_section="no" text_align="left" background_image_as_pattern="without_pattern"][vc_column width="2/3"][vc_column_text] Noelia Lander, a cellular biologist and postdoctoral researcher in Roberto Docampo's laboratory, has received the 2020 Postdoctoral Award from the UGA Research Foundation. Lander has used her research to advance understanding of a dangerous parasite affecting millions of...

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Roberto Docampo, a leading researcher in the study of acidocalcisomes in trypanosomatids

Genetic tool development in marine protists: emerging model organisms for experimental cell biology

[vc_row css_animation="" row_type="row" use_row_as_full_screen_section="no" type="full_width" angled_section="no" text_align="left" background_image_as_pattern="without_pattern"][vc_column width="2/3"][vc_column_text]Diverse microbial ecosystems underpin life in the sea. Among these microbes are many unicellular eukaryotes that span the diversity of the eukaryotic tree of life. However, genetic tractability has been limited to a few species, which do...

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