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Tag: Vasant Muralidharan

Plasmodium falciparum cGMP-dependent protein kinase interacts with a subunit of the parasite proteasome

Donna Huber on October 15, 2018

ABSTRACT Malaria is caused by the protozoan parasite Plasmodium, which undergoes a complex life cycle in a human host and a mosquito vector. The parasite’s cyclic GMP (cGMP)-dependent protein kinase (PKG) is essential at multiple steps of the life cycle. Phosphoproteomic studies in Plasmodium falciparum erythrocytic stages and Plasmodium berghei ookinetes have identified proteolysis as a major biological pathway dependent …

CRISPR/Cas9 Gene Editing to Make Conditional Mutants of Human Malaria Parasite P. falciparum

Donna Huber on September 18, 2018

ABSTRACT Malaria is a significant cause of morbidity and mortality worldwide. This disease, which primarily affects those living in tropical and subtropical regions, is caused by infection with Plasmodium parasites. The development of more effective drugs to combat malaria can be accelerated by improving our understanding of the biology of this complex parasite. Genetic manipulation of these …

Trainee Spotlight: Anat Florentin

Donna Huber on May 30, 2018

Anat Florentin, a post-doctoral associate in Vasant Muralidharan‘s laboratory, is originally from Israel. She received her BSc degree from Tel-Aviv University and MSc from the Weizmann Institute of Science. She obtained her Ph.D. also from the Weizmann Institute where she studied programmed cell death mechanisms using the fruit fly as a model organism. Dr. Florentin …

Anat Florentin receives 2018 Postdoctoral Research Award

Donna Huber on April 23, 2018

Anat Florentin, a postdoctoral researcher in Vasant Muralidharan‘s laboratory at the Center for Tropical and Emerging Global Diseases, studies molecular mechanisms that drive life stages of Plasmodium falciparum, the deadliest of parasite species that infect humans with malaria. During her exceptionally productive years at UGA, she has advanced two related areas of research to learn more about the …

UGA Researcher Seeks to Unlock Secrets of Malaria Parasite

Donna Huber on January 31, 2018

Vasant Muralidharan and his research team at the University of Georgia’s Center for Tropical and Emerging Global Diseases are making great strides in understanding how the malaria parasite hijacks red blood cells to cause disease but many of the parasite’s strategies remain elusive.  A new $1.875 million grant from the National Institutes of Health will …

An ancient bacterial protein complex in human malaria parasites is essential for parasite growth

Donna Huber on November 14, 2017

Several species of Plasmodium parasites cause malaria in humans and results in nearly 450,000 deaths annually. The deadliest of these species is Plasmodium falciparum. Unfortunately, it is also drug resistance to many of the currently available treatments. Vasant Muralidharan, assistant professor in the department of cellular biology, and his research group at The Center for …