Vasant Muralidharan Tag

postdoctoral fellow Lola Fagbami

Fagbami named 2022 Burroughs Wellcome Fund PDEP Fellow

[vc_row css_animation="" row_type="row" use_row_as_full_screen_section="no" type="full_width" angled_section="no" text_align="left" background_image_as_pattern="without_pattern"][vc_column width="2/3"][vc_column_text] [caption id="attachment_7371" align="aligncenter" width="600"] UGA’s Lọla Fagbami, winner of a Burroughs Wellcome Fund 2022 Postdoctoral Diversity Enrichment Program fellowship, is a native of Lagos, Nigeria, who relocated to the United States with her family in the late...

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Activity-based Crosslinking to Identify Substrates of Thioredoxin-domain Proteinsin Malaria Parasites

[vc_row css_animation="" row_type="row" use_row_as_full_screen_section="no" type="full_width" angled_section="no" text_align="left" background_image_as_pattern="without_pattern"][vc_column width="2/3"][vc_column_text]Malaria remains a major public health issue, infecting nearly 220 million people every year. The spread of drug-resistant strains of Plasmodium falciparum around the world threatens the progress made against this disease. Therefore, identifying druggable and essential pathways in P....

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Vasant Muralidharan

Vasant Muralidharan interviewed on The Athens Frontline Podcast

[vc_row css_animation="" row_type="row" use_row_as_full_screen_section="no" type="full_width" angled_section="no" text_align="left" background_image_as_pattern="without_pattern"][vc_column width="2/3"][vc_column_text] Vasant Muralidharan, associate professor of cellular biology and a member of CTEGD, was recently interviewed for The Athens Frontline podcast episode The Next Pandemic. Listen as he discusses mRNA technology, the pandemic, and other emerging diseases.[/vc_column_text][vc_empty_space][vc_raw_html]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[/vc_raw_html][/vc_column][vc_column width="1/3"][vc_widget_sidebar...

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Ale Villegas and Vasant Muralidharan

Ph.D. candidate Ale Villegas and advisor Vasant Muralidharan receive Gilliam Graduate Fellowship Award

[vc_row css_animation="" row_type="row" use_row_as_full_screen_section="no" type="full_width" angled_section="no" text_align="left" background_image_as_pattern="without_pattern"][vc_column width="2/3"][vc_column_text] [caption id="attachment_6635" align="aligncenter" width="600"] PhD Candidate Ale Villegas and Advisor Dr. Vasant Muralidharan (Photo Courtesy of Vasant Muralidharan)[/caption] Malaria’s connection to Georgia goes back to the colonial period. The Southeastern United States provided prime conditions for a thriving...

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Some conditions apply: Systems for studying Plasmodium falciparum protein function

[vc_row css_animation="" row_type="row" use_row_as_full_screen_section="no" type="full_width" angled_section="no" text_align="left" background_image_as_pattern="without_pattern"][vc_column width="2/3"][vc_column_text] [caption id="attachment_6441" align="aligncenter" width="600"] Fig 1. Conditional protein knockdown used throughout the Plasmodium falciparum life cycle.[/caption] Malaria, caused by infection with Plasmodium parasites, remains a significant global health concern. For decades, genetic intractability and limited tools hindered our...

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A redox-active crosslinker reveals an essential and inhibitable oxidative folding network in the endoplasmic reticulum of malaria parasites

[caption id="attachment_6294" align="aligncenter" width="600"] Oxidative folding in the P. falciparum ER[/caption] Malaria remains a major global health problem, creating a constant need for research to identify druggable weaknesses in P. falciparum biology. As important components of cellular redox biology, members of the Thioredoxin (Trx) superfamily of...

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Metabolomics profiling reveals new aspects of dolichol biosynthesis in Plasmodium falciparum

[vc_row css_animation="" row_type="row" use_row_as_full_screen_section="no" type="full_width" angled_section="no" text_align="left" background_image_as_pattern="without_pattern"][vc_column width="2/3"][vc_column_text] The cis-polyisoprenoid lipids namely polyprenols, dolichols and their derivatives are linear polymers of several isoprene units. In eukaryotes, polyprenols and dolichols are synthesized as a mixture of four or more homologues of different length with one or...

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Plastid Biogenesis in Malaria Parasites Requires the Interactions and Catalytic Activity of the Clp Proteolytic System

[vc_row css_animation="" row_type="row" use_row_as_full_screen_section="no" type="full_width" angled_section="no" text_align="left" background_image_as_pattern="without_pattern"][vc_column width="2/3"][vc_column_text]The human malaria parasite, Plasmodium falciparum, contains an essential plastid called the apicoplast. Most apicoplast proteins are encoded by the nuclear genome and it is unclear how the plastid proteome is regulated. Here, we study an apicoplast-localized caseinolytic-protease...

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Directing Traffic: Chaperone-mediated protein transport in malaria parasites

[vc_row css_animation="" row_type="row" use_row_as_full_screen_section="no" type="full_width" angled_section="no" text_align="left" background_image_as_pattern="without_pattern"][vc_column width="2/3"][vc_column_text]The ability of eukaryotic parasites from the phylum Apicomplexa to cause devastating diseases is predicated upon their ability to maintain faithful and precise protein trafficking mechanisms. Their parasitic life cycle depends on the trafficking of effector proteins...

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