Dennis Kyle Archives - Page 7 of 9 - Center for Tropical and Emerging Global Diseases

Trainee Spotlight: Alona Botnar

Donna Huber on August 18, 2020

T32 trainee Alona Botnar is entering her fifth year as a Ph.D. candidate in Dr. Dennis Kyle’s laboratory. She is from Doylestown, Pennsylvania and completed her B.S. in Chemistry with a minor in Biochemistry at the University of Georgia in 2015. During her undergraduate career, she also worked at Janssen, a pharmaceutical company of Johnson …

Trainee Spotlight: Emma Troth

Donna Huber on July 23, 2020

Emma Troth, a Ph.D. trainee in Dennis Kyle's laboratory, is entering her fourth year at UGA. She is originally from Eureka, Illinois, and attended Bradley University where she majored in Biology with a minor in Ethics. While at UGA, Emma has served as president of the CTEGD Graduate Student Association (2019-2020) and is currently the …

Bioactivity of Spongian Diterpenoid Scaffolds From the Antarctic Sponge Dendrilla antarctica

Donna Huber on June 23, 2020

The Antarctic sponge Dendrilla antarctica is rich in defensive terpenoids with promising antimicrobial potential. Investigation of this demosponge has resulted in the generation of a small chemical library containing diterpenoid secondary metabolites with bioactivity in an infectious disease screening campaign focused on Leishmania donovani, Plasmodium falciparum, and methicillin-resistant Staphylococcus aureus (MRSA) biofilm. In total, eleven natural products were isolated, including three …

Dynamics of Infection and Pathology Induced by the Aporocotylid, Cardicola Laruei, in Spotted Seatrout, Cynoscion Nebulosus (Sciaenidae)

Donna Huber on June 19, 2020

The sciaenid Spotted Seatrout (Cynoscion nebulosus) are infected by blood flukes (Cardicola spp.). A 2 year survey in estuaries of South Carolina, USA, showed that adult flukes and granulomas occurred throughout the year but their prevalence was highest in summer (61% and 84%, respectively), indicating an unusually high level of infection for wild fish. Granulomas …

Discovery of Anti-Amoebic Inhibitors from Screening the MMV Pandemic Response Box on Balamuthia mandrillaris, Naegleria fowleri, and Acanthamoeba castellanii

Donna Huber on June 16, 2020

Pathogenic free-living amoebae, Balamuthia mandrillaris, Naegleria fowleri, and several Acanthamoeba species are the etiological agents of severe brain diseases, with case mortality rates > 90%. A number of constraints including misdiagnosis and partially effective treatments lead to these high fatality rates. The unmet medical need is for rapidly acting, highly potent new drugs to reduce these alarming mortality rates. …

Dennis Kyle elected as American Academy of Microbiology Fellow

Donna Huber on March 31, 2020

University of Georgia researcher Dennis Kyle has been elected as a 2020 fellow by the American Academy of Microbiology. He joins a class of 68 new fellows this year. Kyle is a GRA Eminent Scholar in antiparasitic drug discovery, with appointments in the departments of cellular biology and infectious diseases. “Election as a Fellow of …

Plasmodium vivax Liver and Blood Stages Recruit the Druggable Host Membrane Channel Aquaporin-3

Donna Huber on March 24, 2020

Plasmodium vivax infects hepatocytes to form schizonts that cause blood infection, or dormant hypnozoites that can persist for months in the liver before leading to relapsing blood infections. The molecular processes that drive P. vivax schizont and hypnozoite survival remain largely unknown, but they likely involve a rich network of host-pathogen interactions, including those occurring at the host-parasite interface, …

Battling Malaria

Donna Huber on February 28, 2020

UGA is developing new drugs to fight a lethal parasite. Dennis Kyle discusses what his lab is doing to fight malaria in this brief (2:30) video. HELP BATTLE DEADLY DISEASES Donate to the Center for Tropical and Emerging Global Diseases Give Now

In vitro screening of the open source MMV Malaria and Pathogen Boxes to discover novel compounds with activity against Balamuthia mandrillaris

Donna Huber on February 18, 2020

Balamuthia mandrillaris, is an under reported pathogenic free-living amoeba that causes Balamuthia amoebic encephalitis (BAE) and cutaneous skin infections. Although cutaneous infections are not typically lethal, BAE with or without cutaneous involvement usually is fatal. This is due to lack of drugs that are efficacious and that can cross the blood-brain barrier. We aimed to discover new …

An adaptable soft-mold embossing process for fabricating optically-accessible, microfeature-based culture systems and application toward liver stage antimalarial compound testing

Donna Huber on February 14, 2020

Advanced cell culture methods for modeling organ-level structure have been demonstrated to replicate in vivo conditions more accurately than traditional in vitro cell culture. Given that the liver is particularly important to human health, several advanced culture methods have been developed to experiment with liver disease states, including infection with Plasmodium parasites, the causative agent …

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