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Category: publications

Temporal Variation in Target Site Mutations Is Associated with Diamide Cross-Resistance in Diamondback Moth Populations (Lepidoptera: Plutellidae) from Florida and Georgia, USA

Donna Huber on November 19, 2025

The Diamondback moth (DBM), Plutella xylostella (L.), the most significant worldwide pest of Brassica crops, is notorious for resistance to a diverse number of insecticides. Field populations bioassayed in Georgia and Florida, USA, in 2018 were resistant to chlorantraniliprole but susceptible to cyantraniliprole. Subsequently, populations assayed in 2021, 2022, and 2023 were cross-resistant to both diamides. We used NextSeq …

Selenocyanate-Containing Molecules as Trypanosoma cruzi Inhibitors: Impact of Regioisomerism, Conformational Restriction, and Second-Ring Substitution

Donna Huber on November 11, 2025

As a continuation of the project aimed at searching for new chemotherapeuticagents against Chagas disease or American trypanosomiasis, new selenocyanate derivatives are designed, synthesized, and biologically evaluated against the clinically more relevant dividing amastigote form of Trypanosoma cruzi, the etiologic agent of this illness. Furthermore, as all the title compounds are fluorine-containing molecules, it seemed …

Genomic Characterization of Cryptosporidium spp. via iNextEra Library Preparation and Hybridization Bait Capture

Donna Huber on October 28, 2025

Next-generation DNA sequencing (NGS) is used to study the genome sequences of Cryptosporidium spp., but NGS is challenging when pure Cryptosporidium oocysts are limited in number or not available. Varying levels of parasites present in fecal samples, combined with the abundance of host cells, bacterial and other microbial cells, and undigested food particles, often result …

More extraordinary model systems for regeneration

Donna Huber on October 28, 2025

  The ability of organisms to replace and regenerate anatomical structures following their loss or damage has piqued the curiosity of biologists for centuries. In addition to Development’s ‘Model systems for regeneration’ collection, which introduced some of the most well-studied model organisms in the field, we published a Perspective in 2024 highlighting some of the …

Characterization of β-Carboline Derivatives Reveals a High Barrier to Resistance and Potent Activity against Ring-Stage and DHA-Induced Dormant Plasmodium falciparum

Donna Huber on October 17, 2025

Malaria, caused by Plasmodium falciparum, remains a major global health challenge, with an estimated 263 million new infections and 597,000 deaths annually. Increasing resistance to current antimalarial drugs underscores the urgent need for new therapeutics that target novel pathways in the parasite. We previously reported a novel class of β-carboline antimalarials, exemplified by PRC1584, which demonstrated …

Amplicon sequencing detects, identifies, and quantifies minority variants in mixed-species infections of Cryptosporidium parasites

Donna Huber on October 8, 2025

  Cryptosporidium is a globally endemic parasite genus with over 40 recognized species. While C. hominis and C. parvum are responsible for most human infections, human cases involving other species have also been reported. Furthermore, there is increasing evidence of simultaneous infections with multiple species. Therefore, we devised a new means to identify various species of Cryptosporidium in mixed infections by sequencing …

Large DNA Viruses That Parasitoid Wasps Transmit to Hosts

Donna Huber on October 7, 2025

Many types of viruses have been identified in parasitoid wasps and other Hymenoptera. Parasitoid wasps also transmit several viruses to hosts through the piercing ovipositors that females use to lay eggs. Most viruses that are known to be transmitted by parasitoids have large double-stranded DNA genomes. We summarize the range of interactions that have evolved …

Signals from the head and germinative region differentially regulate regeneration competence of the tapeworm Hymenolepis diminuta

Donna Huber on October 7, 2025

Competence to regenerate lost tissues varies widely across species. The rat tapeworm, Hymenolepis diminuta, undergoes continual cycles of shedding and regenerating thousands of reproductive segments to propagate the species. Despite its prowess, H. diminuta can only regenerate posteriorly from a singular tissue: the neck or germinative region (GR). What cells and signaling pathways restrict regeneration …

Insulin-like peptides activate egg formation in the Asian malaria mosquito Anopheles stephensi

Donna Huber on October 7, 2025

Background: The mosquito family Culicidae diverged into the subfamilies Anophelinae and Culicinae approximately 179 million years ago. Most female mosquitoes are anautogenous and must blood-feed on a vertebrate to produce eggs. Regulation of egg-producing gonotrophic cycles is best understood in the culicine Aedes aegypti. Anopheline mosquitoes encode all of the hormones that regulate gonotrophic cycles in …