University of Georgia
Generic selectors
Exact matches only
Search in title
Search in content
Post Type Selectors

Author: Donna Huber

Nationwide Remapping of Schistosoma mansoni Infection in Rwanda Using Circulating Cathodic Antigen Rapid Test: Taking Steps Toward Elimination

Donna Huber on May 18, 2020

Eugene Ruberanziza, Udo Wittmann, Aimable Mbituyumuremyi, Alphonse Mutabazi, Carl H. Campbell Jr, Daniel G. Colley, Fiona M. Fleming, Giuseppina Ortu, Govert J. van Dam, Irenee Umulisa, Jamie Tallant, Michee Kabera, Muhammed Semakula, Paul L. A. M. Corstjens, Tharcisse Munyaneza, Warren Lancaster, Jean Bosco Mbonigaba and Michelle N. Clements. Am J Trop Med Hyg. 2020 May 18. doi: 10.4269/ajtmh.19-0866.

A terminal α3-galactose modification regulates an E3 ubiquitin ligase subunit in Toxoplasma gondii

Donna Huber on May 15, 2020

Skp1, a subunit of E3 Skp1/Cullin-1/F-box protein ubiquitin ligases, is modified by a prolyl hydroxylase that mediates O2-regulation of the social amoeba Dictyostelium and the parasite Toxoplasma gondii. The full effect of hydroxylation requires modification of the hydroxyproline by a pentasaccharide that, in Dictyostelium, influences Skp1 structure to favor assembly of Skp1/F-box protein subcomplexes. In Toxoplasma, the presence of a contrasting …

Antimalarial Diterpenoids From Vitex Rotundifolia: Isolation, Structure Elucidation, and in Vitro Antiplasmodial Activity

Donna Huber on May 12, 2020

Vitex rotundifolia is an important medicinal plant frequently employed in traditional medicines for the treatment of various ailments. Although this plant species has been under exploration for its constituents by various research groups including our own group, no reports were found regarding the antimalarial potential of this plant or of its purified phytochemicals. Phytochemical investigation …

Supplemental Articles: Operational Research on Controlling and Eliminating Schistosomiasis (SCORE)

Donna Huber on May 12, 2020

These articles are available online ahead of print and summarize much of the work of the Schistosomiasis Consortium for Operational Research and Evaluation (SCORE). The articles will be published as a supplement to the July issue of The American Journal of Tropical Medicine and Hygiene. Schistosomiasis Consortium for Operational Research and Evaluation: Mission Accomplished The …

Directing Traffic: Chaperone-mediated protein transport in malaria parasites

Donna Huber on May 9, 2020

The ability of eukaryotic parasites from the phylum Apicomplexa to cause devastating diseases is predicated upon their ability to maintain faithful and precise protein trafficking mechanisms. Their parasitic life cycle depends on the trafficking of effector proteins to the infected host cell, transport of proteins to several critical organelles required for survival, as well as …

Ynes Ortega receives grant to study Cyclospora presence in the U.S.

Donna Huber on May 5, 2020

Historically, Cyclospora infection in the United States has been associated with imported fresh produce. However, in 2018, the U.S. saw two significant outbreaks associated with vegetables grown in the United States. “We had more than 2,000 non-travel associates cyclosporiasis cases,” said Ynes Ortega, member of the Center for Tropical and Emerging Global Diseases and associate …

Global Schistosomiasis Alliance pays tribute to Dan Colley

Donna Huber on April 28, 2020

Dan Colley in his lab at UGA (photo credit: Andrew Tucker)   Dr. Daniel G. Colley, Director of the Schistosomiasis Consortium for Operational Research and Evaluation (SCORE), will be retiring from his position as Professor at the University of Georgia on June 30, 2020. He will continue as a Professor Emeritus. The Global Schistosomiasis Alliance …

Design, Synthesis, and Evaluation of Novel Anti-Trypanosomal Compounds

Donna Huber on April 17, 2020

Human African trypanosomiasis (HAT) is a deadly neglected tropical disease caused by the protozoan parasite Trypanosoma brucei. During the course of screening a collection of diverse nitrogenous heterocycles, we discovered two novel compounds that contain the tetracyclic core of the Yohimbine and Corynanthe alkaloids, were potent inhibitors of T. brucei proliferation and T. brucei methionyl-tRNA synthetase (TbMetRS) activity. Inspired by these key …

Noelia Lander receives research award

Donna Huber on April 9, 2020

Noelia Lander, a cellular biologist and postdoctoral researcher in Roberto Docampo's laboratory, has received the 2020 Postdoctoral Award from the UGA Research Foundation. Lander has used her research to advance understanding of a dangerous parasite affecting millions of people worldwide. She adapted the CRISPR/Cas9 genome-editing system for the study of Trypanosoma cruzi, a human parasite that …