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Author: Donna Huber

Activity-based Crosslinking to Identify Substrates of Thioredoxin-domain Proteinsin Malaria Parasites

Donna Huber on February 20, 2022

Malaria remains a major public health issue, infecting nearly 220 million people every year. The spread of drug-resistant strains of Plasmodium falciparum around the world threatens the progress made against this disease. Therefore, identifying druggable and essential pathways in P. falciparum parasites remains a major area of research. One poorly understood area of parasite biology is the formation of …

Protozoan phagotrophy from predators to parasites: An overview of the enigmatic cytostome-cytopharynx complex of Trypanosoma cruzi

Donna Huber on February 17, 2022

Eating is fundamental and from this basic principle, living organisms have evolved innumerable strategies to capture energy and nutrients from their environment. As part of the world's aquatic ecosystems, the expansive family of heterotrophic protozoans uses self-generated currents to funnel prokaryotic prey into an ancient, yet highly enigmatic, oral apparatus known as the cytostome-cytopharynx complex …

The good, the bad, and the ugly: From planarians to parasites

Donna Huber on February 16, 2022

Platyhelminthes can perhaps rightly be described as a phylum of the good, the bad, and the ugly: remarkable free-living worms that colonize land, river, and sea, which are often rife with color and can display extraordinary regenerative ability; parasitic worms like schistosomes that cause devastating disease and suffering; and monstrous tapeworms that are the stuff …

Trainee Spotlight: Justine Shiau

Donna Huber on February 9, 2022

Justine Shiau, an NIH T32 fellow in Dr. Dennis Kyle's laboratory, is originally from Taipei, Taiwan, and moved to the states after elementary school. She received her bachelor's degree in Biology from the Pennsylvania State University, where she became interested in disease transmission, disease ecology, and parasitology while working with Dr. Ashutosh Pathak. Upon graduation, …

Differential Growth Rates and In Vitro Drug Susceptibility to Currently Used Drugs for Multiple Isolates of Naegleria fowleri

Donna Huber on February 9, 2022

The free-living amoeba Naegleria fowleri, which typically dwells within warm, freshwater environments, can opportunistically cause primary amoebic meningoencephalitis (PAM), a disease with a mortality rate of >97%. The lack of positive treatment outcomes for PAM has prompted the discovery and development of more effective therapeutics, yet most studies utilize only one or two clinical isolates. …

Insulin-like peptide 3 stimulates hemocytes to proliferate in anautogenous and facultatively autogenous mosquitoes

Donna Huber on February 7, 2022

Most mosquito species are anautogenous, which means they must blood feed on a vertebrate host to produce eggs, while a few are autogenous and can produce eggs without blood feeding. Egg formation is best understood in the anautogenous mosquito Aedes aegypti where insulin-like peptides (ILPs), ovary ecdysteroidogenic hormone (OEH) and 20-hydroxyecdysone (20E) interact to regulate …

CRISPR/Cas9-induced disruption of Bodo saltans paraflagellar rod-2 gene reveals its importance for cell survival

Donna Huber on January 31, 2022

Developing transfection protocols for marine protists is an emerging field that will allow the functional characterization of protist genes and their roles in organism responses to the environment. We developed a CRISPR/Cas9 editing protocol for Bodo saltans, a free-living kinetoplastid with tolerance to both marine and freshwater conditions, and a close non-parasitic relative of trypanosomatids. …

Jessica Kissinger elected as AAAS Fellow

Donna Huber on January 27, 2022

Dr. Jessica Kissinger with student Three University of Georgia faculty have been named Fellows of the American Association for the Advancement of Science. In a tradition stretching back to 1874, these individuals are elected annually by the AAAS Council for their extraordinary achievements leading to the advancement of science. Fellows must have been AAAS members for …

Cytometry Shared Resource Lab expands capabilities with new instrument

Donna Huber on January 20, 2022

Julie Nelson, CSRL manager, is available to train users on the newly acquire CYTEK Aurora flow cytometer. (photo credit: Donna Huber) With the generous financial support of The Office of Research, Cytometry Shared Resource Lab, Center for Tropical and Emerging Global Diseases, Department of Infectious Diseases, and UGA faculty members Rick Tarleton, Mark Tompkins, Chet …