University of Georgia

Stephen Hajduk Tag

Hypothesis-generating proteome perturbation to identify NEU-4438 and acoziborole modes of action in the African Trypanosome

Posted on Oct 7, 2022 in publications
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[vc_row css_animation="" row_type="row" use_row_as_full_screen_section="no" type="full_width" angled_section="no" text_align="left" background_image_as_pattern="without_pattern"][vc_column width="2/3"][vc_column_text] NEU-4438 is a lead for the development of drugs against Trypanosoma brucei, which causes human African trypanosomiasis. Optimized with phenotypic screening, targets of NEU-4438 are unknown. Herein, we present a cell perturbome workflow that compares NEU-4438's molecular modes...

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Hajduk Stephen

Turnover of Variant Surface Glycoprotein in Trypanosoma brucei Is a Bimodal Process

Posted on Jul 28, 2021 in publications
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[vc_row css_animation="" row_type="row" use_row_as_full_screen_section="no" type="full_width" angled_section="no" text_align="left" background_image_as_pattern="without_pattern"][vc_column width="2/3"][vc_column_text]African trypanosomes utilize glycosylphosphatidylinositol (GPI)-anchored variant surface glycoprotein (VSG) to evade the host immune system. VSG turnover is thought to be mediated via cleavage of the GPI anchor by endogenous GPI-specific phospholipase C (GPI-PLC). However, GPI-PLC is...

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Lexis and Grammar of Mitochondrial RNA Processing in Trypanosomes

Posted on Feb 28, 2020 in publications
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[vc_row css_animation="" row_type="row" use_row_as_full_screen_section="no" type="full_width" angled_section="no" text_align="left" background_image_as_pattern="without_pattern"][vc_column width="2/3"][vc_column_text]Trypanosoma brucei spp. cause African human and animal trypanosomiasis, a burden on health and economy in Africa. These hemoflagellates are distinguished by a kinetoplast nucleoid containing mitochondrial DNAs of two kinds: maxicircles encoding ribosomal RNAs (rRNAs) and...

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Grad school ready

Posted on Oct 2, 2018 in CTEGD Blog
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by Camie Williams   [caption id="attachment_4778" align="aligncenter" width="810"] PREP@UGA Scholar Jilarie Santos Santiago, center, consults with her faculty mentor Stephen Hajduk, left, and postdoctoral mentor Michael Cipriano. (Photo by Dorothy Kozlowski)[/caption] PREP@UGA Scholars program trains next generation of life sciences researchers. As an undergraduate student in Maryland, Ian Liyayi planned to...

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