Center for Tropical and Emerging Global Diseases
University of Georgia
New test protocol can detect low levels of Trypanosoma cruzi, the parasite that causes Chagas disease Researchers at the University of Georgia’s Center for Tropical and Emerging Global Diseases have developed the first test to determine whether treatment for Chagas disease was effective. An estimated 6 million to 8 million people worldwide are infected with …
UGA researchers develop first test of cure for Chagas disease (UGA Today) UGA Pioneers First Test for Chagas Disease Cure (Mirage) UGA researchers develop first test of cure for Chagas disease (Newswise) ¿Se curó la infección de Chagas? Un nuevo test podría dar la respuesta (Infobae) Chagas disease: Test for cure (Outbreak News Today) AN2 …
CD8+ T cells are key effectors in immune control of Trypanosoma cruzi infection. Within C57BL/6 mice, the T. cruzi-specific CD8+ T cell response is largely comprised of T cells recognizing trans-sialidase (TS)- and mucin-encoded epitopes. Despite their immunodominance, these epitope-specific CD8+ T cells are entirely dispensable for immune control. In a screen for epitopes inducing …
Trypanosoma cruzi typically establishes a life-long infection in its mammalian hosts, causing the destruction of muscle tissues and ultimately resulting in potentially fatal Chagas disease. In this review, we consider the array of avoidance mechanisms that allow for T. cruzi persistence, many of which are unconventional among protozoan pathogens but which collectively are highly effective …
Researchers secure funding to advance Chagas disease research (News-Medical.net) Investigators are studying Chagas disease with a One Health approach (DVM360) UGA and Texas A&M Researchers tackle Chagas disease in dogs and humans (WUGA) Countable Labs Launches Single-Molecule DNA Counting System, PCR Application (GenomeWeb)
Infection with the protozoan parasite Trypanosoma cruzi is generally well-controlled by host immune responses, but appears to be rarely eliminated. The resulting persistent, low-level infection results in cumulative tissue damage with the greatest impact generally in the heart in the form of chagasic cardiomyopathy. The relative success in immune control of T. cruzi infection usually …
Background: Chagas disease or American trypanosomiasis, caused by Trypanosoma cruzi and vectored by triatomines, affects millions of people worldwide. In endemic countries including Mexico, infections in domestic animals, such as dogs, may affect the risk of human disease when they serve as a source of infection to vectors that subsequently infect humans. Materials and Methods: We conducted a cross-sectional study …
Trypanosoma cruzi, the protozoan parasite and cause of Chagas disease, is widely distributed in many vertebrate and triatomine species throughout North, Central, and South America. Variations in housing quality largely determines human infection risk in the Americas. However, the southern U.S. contains widespread, infected triatomine vectors and captive species and domesticated animals with active T. cruzi infection …
