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Tag: Dan Colley

The Life & Times of the SchistoKid – People, Parasites, and Plagues podcast

Donna Huber on January 2, 2025

Daniel Colley visits a car wash in Kisumu, Kenya, one of his study sites for more than 20 years. Workers at the car wash drive vehicles into Lake Victoria, infecting and reinfecting themselves with schistosomiasis. (Photo courtesy of SCORE) Professor Emeritus Daniel Colley is the featured guest on the People, Parasites, and Plagues podcast. Learn …

Review of 2022 WHO guidelines on the control and elimination of schistosomiasis

Donna Huber on May 17, 2022

Schistosomiasis is a helminthiasis infecting approximately 250 million people worldwide. In 2001, the World Health Assembly (WHA) 54.19 resolution defined a new global strategy for control of schistosomiasis through preventive chemotherapy programmes. This resolution culminated in the 2006 WHO guidelines that recommended empirical treatment by mass drug administration with praziquantel, predominately to school-aged children in …

Effect of preventive chemotherapy with praziquantel on schistosomiasis among school-aged children in sub-Saharan Africa: a spatiotemporal modelling study

Donna Huber on December 2, 2021

Background: Over the past 20 years, schistosomiasis control has been scaled up. Preventive chemotherapy with praziquantel is the main intervention. We aimed to assess the effect of preventive chemotherapy on schistosomiasis prevalence in sub-Saharan Africa, comparing 2000-10 with 2011-14 and 2015-19. Methods: In this spatiotemporal modelling study, we analysed survey data from school-aged children (aged 5-14 years) …

Outhouses, clean water key to fighting schistosomiasis in persistent hotspots

Donna Huber on October 11, 2021

Dan Colley, professor emeritus of microbiology and former director of the Center for Tropical and Emerging Global Diseases, devoted much of his career to studying schistosomiasis, a disease caused by waterborne parasites that is endemic in several African nations. (photo credit: Andrew Tucker) Schistosomiasis, caused by several species of the parasitic worm Schistosoma, is a …

Unprotected water sources and low latrine coverage are contributing factors to persistent hotspots for schistosomiasis in western Kenya

Donna Huber on September 17, 2021

Background: Evidence indicates that whereas repeated rounds of mass drug administration (MDA) programs have reduced schistosomiasis prevalence to appreciable levels in some communities referred to here as responding villages (R). However, prevalence has remained high or less than anticipated in other areas referred to here as persistent hotspot villages (PHS). Using a cross-sectional quantitative approach, this …

Estimating true prevalence of Schistosoma mansoni from population summary measures based on the Kato-Katz diagnostic technique

Donna Huber on April 6, 2021

Background: The prevalence of Schistosoma mansoni infection is usually assessed by the Kato-Katz diagnostic technique. However, Kato-Katz thick smears have low sensitivity, especially for light infections. Egg count models fitted on individual level data can adjust for the infection intensity-dependent sensitivity and estimate the 'true' prevalence in a population. However, application of these models is complex …

Test, Treat, Track, Test, and Treat Active Surveillance toward Elimination of Schistosomiasis: A Feasibility Study

Donna Huber on July 13, 2020

We assessed the feasibility of using a test, treat, track, test, and treat (5T) active surveillance strategy to identify and treat individuals with schistosomiasis in three very low-prevalence villages in Kafr El Sheikh Governorate, Egypt. Primary index cases (PICs) were identified using the point-of-care circulating cathodic antigen (POC-CCA) assay in schools, in rural health units …

SCORE – a decade of operational research with a lasting legacy

Donna Huber on July 10, 2020

It all began with a simple phone call and now, more than a decade later, the Schistosomiasis Consortium for Operational Control and Evaluation (SCORE) is preparing to pass the baton to new groups of investigators working on understanding and controlling schistosomiasis. Under the direction of Dan Colley, a member of the Center for Tropical and …

Evaluation of Morbidity in Schistosoma Mansoni-Positive Primary and Secondary School Children After Four Years of Mass Drug Administration of Praziquantel in Western Kenya

Donna Huber on June 15, 2020

Background: World Health Organization guidelines recommend preventive chemotherapy with praziquantel to control morbidity due to schistosomiasis. The primary aim of this cross-sectional study was to determine if 4 years of annual mass drug administration (MDA) in primary and secondary schools lowered potential markers of morbidity in infected children 1 year after the final MDA compared to …