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Tag: Belen Cassera

Isolation and characterization of antiplasmodial constituents from the marine sponge Coscinoderma sp.

Donna Huber on August 6, 2019

Six known compounds, namely two halisulfates 1 and 2 and four epidioxy sterols 3–6, were isolated from the marine sponge Coscinoderma sp. The structures of these compounds were confirmed by nuclear magnetic resonance (1H and 13C NMR) spectroscopy, and their antiplasmodial activities were determined against the chloroquine-resistant Dd2 strain of Plasmodium falciparum. The epidioxy steroids 3–6 all showed moderate to weak antiplasmodial activity, with IC50 values of …

Researchers receive $2M NIH instrumentation grant

Donna Huber on January 8, 2019

by Alan Flurry The National Institutes of Health has awarded University of Georgia researchers $1.956 million for a high-resolution mass spectrometer that will enhance capabilities for scientists in many fields across campus. The award by the NIH High End Instrumentation program, which provides grants in the range of $600,000 to $2 million for a variety of expensive …

Phloroglucinols from the Roots of Garcinia dauphinensis and Their Antiproliferative and Antiplasmodial Activities

Donna Huber on October 24, 2018

  Abstract Garcinia dauphinensis is a previously uninvestigated endemic plant species of Madagascar. The new phloroglucinols dauphinols A–F and 3′-methylhyperjovoinol B (1–7) and six known phloroglucinols (8–13) together with tocotrienol 14 and the three triterpenoids 15–17 were isolated from an ethanolic extract of G. dauphinensis roots using various chromatographic techniques. The structures of the isolated compounds were elucidated by NMR, MS, optical …

Trainee Spotlight: Josh Butler

Donna Huber on September 18, 2018

New T32 trainee Josh Butler is a third year Ph.D. student in Belen Cassera‘s laboratory. He is from Front Royal, Virginia and completed his B.S. in chemistry at James Madison University in Harrisonburg, Virginia. Butler decided to pursue his graduate degree at the University of Georgia because of the Integrate Life Sciences program which offers …

Antiplasmodial flavanones and a stilbene from Carpha glomerata

Donna Huber on September 4, 2018

  Abstract Bioassay-guided fractionation of an extract of Carpha glomerata (Cyperaceae) led to the isolation of seven compounds. Compounds 1 (carphorin A), 3 (carphorin C), 4(carphorin D), and 5 (carphabene) are new compounds, and compound 2 (8-(3″-hydroxyisoamyl)-naringenin) was isolated for the first time as a natural product. All structures were elucidated based on analyses of their HR-ESIMS and 1D and 2D NMR data. Compounds 1, 2, and 6, which …

Visiting Scholar: Elvis Ofori Ameyaw

Donna Huber on February 8, 2018

  Elvis Ofori Ameyaw is a Fulbright Scholar visiting M. Belen Cassera‘s laboratory in the department of molecular biology and biochemistry. He is a senior lecturer, Head of the Department of Biomedical Sciences and the Vice-Dean of the School of Allied Health Sciences in the College of Health and Allied Sciences at the University of Cape Coast …

New UGA Drug Discovery Core lab works to develop treatment of leading diseases

Donna Huber on November 8, 2017

Athens, Ga. – The University of Georgia has created the Drug Discovery Core laboratory, a campus-wide collaborative facility designed to hasten the development of therapeutic drugs for a number of major diseases. A survey distributed to UGA researchers in 2016 identified chemical screening and toxicity profiling as the most critical needs for enhancing drug discovery …