Author: Donna Huber

Enantiopure Benzofuran-2-carboxamides of 1-Aryltetrahydro-β-carbolines Are Potent Antimalarials In Vitro

Posted on Feb 24, 2022 in publications

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Malaria Box-Inspired Discovery of N-Aminoalkyl-β-carboline-3-carboxamides, a Novel Orally Active Class of Antimalarials

Posted on Feb 23, 2022 in publications

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[vc_row css_animation="" row_type="row" use_row_as_full_screen_section="no" type="full_width" angled_section="no" text_align="left" background_image_as_pattern="without_pattern"][vc_column width="2/3"][vc_column_text]Virtual ligand screening of a publicly available database of antimalarial hits using a pharmacophore derived from antimalarial MMV008138 identified TCMDC-140230, a tetrahydro-β-carboline amide, as worthy of exploration. All four stereoisomers of this structure were synthesized, but none...

Roberto Docampo, a leading researcher in the study of acidocalcisomes in trypanosomatids

New insights into the role of acidocalcisomes in trypanosomatids

Posted on Feb 21, 2022 in publications

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[vc_row css_animation="" row_type="row" use_row_as_full_screen_section="no" type="full_width" angled_section="no" text_align="left" background_image_as_pattern="without_pattern"][vc_column width="2/3"][vc_column_text]Acidocalcisomes are electron-dense organelles rich in polyphosphate and inorganic and organic cations that are acidified by proton pumps, and possess several channels, pumps and transporters. They are present in bacteria and eukaryotes and have been studied in...

Activity-based Crosslinking to Identify Substrates of Thioredoxin-domain Proteinsin Malaria Parasites

Posted on Feb 20, 2022 in publications

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[vc_row css_animation="" row_type="row" use_row_as_full_screen_section="no" type="full_width" angled_section="no" text_align="left" background_image_as_pattern="without_pattern"][vc_column width="2/3"][vc_column_text]Malaria remains a major public health issue, infecting nearly 220 million people every year. The spread of drug-resistant strains of Plasmodium falciparum around the world threatens the progress made against this disease. Therefore, identifying druggable and essential pathways in P....

Protozoan phagotrophy from predators to parasites: An overview of the enigmatic cytostome-cytopharynx complex of Trypanosoma cruzi

Posted on Feb 17, 2022 in publications

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The good, the bad, and the ugly: From planarians to parasites

Posted on Feb 16, 2022 in publications

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[vc_row css_animation="" row_type="row" use_row_as_full_screen_section="no" type="full_width" angled_section="no" text_align="left" background_image_as_pattern="without_pattern"][vc_column width="2/3"][vc_column_text]Platyhelminthes can perhaps rightly be described as a phylum of the good, the bad, and the ugly: remarkable free-living worms that colonize land, river, and sea, which are often rife with color and can display extraordinary regenerative...

Trainee Spotlight: Justine Shiau

Posted on Feb 9, 2022 in CTEGD Blog

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[vc_row css_animation="" row_type="row" use_row_as_full_screen_section="no" type="full_width" angled_section="no" text_align="left" background_image_as_pattern="without_pattern"][vc_column width="2/3"][vc_column_text] Justine Shiau, an NIH T32 fellow in Dr. Dennis Kyle's laboratory, is originally from Taipei, Taiwan, and moved to the states after elementary school. She received her bachelor's degree in Biology from the Pennsylvania State University, where...

Differential Growth Rates and In Vitro Drug Susceptibility to Currently Used Drugs for Multiple Isolates of Naegleria fowleri

Posted on Feb 9, 2022 in publications

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[vc_row css_animation="" row_type="row" use_row_as_full_screen_section="no" type="full_width" angled_section="no" text_align="left" background_image_as_pattern="without_pattern"][vc_column width="2/3"][vc_column_text]The free-living amoeba Naegleria fowleri, which typically dwells within warm, freshwater environments, can opportunistically cause primary amoebic meningoencephalitis (PAM), a disease with a mortality rate of >97%. The lack of positive treatment outcomes for PAM has prompted...

Insulin-like peptide 3 stimulates hemocytes to proliferate in anautogenous and facultatively autogenous mosquitoes

Posted on Feb 7, 2022 in publications

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[vc_row css_animation="" row_type="row" use_row_as_full_screen_section="no" type="full_width" angled_section="no" text_align="left" background_image_as_pattern="without_pattern"][vc_column width="2/3"][vc_column_text]Most mosquito species are anautogenous, which means they must blood feed on a vertebrate host to produce eggs, while a few are autogenous and can produce eggs without blood feeding. Egg formation is best understood in the...

Vasant Muralidharan interviewed on The Athens Frontline Podcast

Posted on Feb 4, 2022 in CTEGD Blog

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[vc_row css_animation="" row_type="row" use_row_as_full_screen_section="no" type="full_width" angled_section="no" text_align="left" background_image_as_pattern="without_pattern"][vc_column width="2/3"][vc_column_text] Vasant Muralidharan, associate professor of cellular biology and a member of CTEGD, was recently interviewed for The Athens Frontline podcast episode The Next Pandemic. Listen as he discusses mRNA technology, the pandemic, and other emerging diseases.[/vc_column_text][vc_empty_space][vc_raw_html]JTNDaWZyYW1lJTIwdGl0bGUlM0QlMjJUaGUlMjBOZXh0JTIwUGFuZGVtaWMlMjIlMjBoZWlnaHQlM0QlMjI0MDAlMjIlMjB3aWR0aCUzRCUyMjEwMCUyNSUyMiUyMHN0eWxlJTNEJTIyYm9yZGVyJTNBJTIwbm9uZSUzQiUyMiUyMHNjcm9sbGluZyUzRCUyMm5vJTIyJTIwZGF0YS1uYW1lJTNEJTIycGItaWZyYW1lLXBsYXllciUyMiUyMHNyYyUzRCUyMmh0dHBzJTNBJTJGJTJGd3d3LnBvZGJlYW4uY29tJTJGcGxheWVyLXYyJTJGJTNGc2hhcmUlM0QxJTI2ZG93bmxvYWQlM0QxJTI2cnRsJTNEMCUyNmZvbnRzJTNEQXJpYWwlMjZza2luJTNEMWIxYjFiJTI2Zm9udC1jb2xvciUzRGF1dG8lMjZidG4tc2tpbiUzRGM3M2EzYSUyNm11bHRpcGxlX3NpemUlM0QzMTUlMjZzcXVhcmVfc2l6ZSUzRDMwMCUyNm9yZGVyJTNEZXBpc29kaWMlMjZmaWx0ZXIlM0RhbGwlMjZsaW1pdCUzRDEwJTI2c2Vhc29uJTNEYWxsJTI2dGFnJTNEYWxsJTI2c3F1YXJlJTNEMSUyNmklM0R1Yms2ZC0xMTk2ZjhjLXBiJTIyJTIwYWxsb3dmdWxsc2NyZWVuJTNEJTIyJTIyJTNFJTNDJTJGaWZyYW1lJTNF[/vc_raw_html][/vc_column][vc_column width="1/3"][vc_widget_sidebar...

Author: Donna Huber

CTEGD

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