Author: Donna Huber

M. Belen Cassera

Enantiopure Benzofuran-2-carboxamides of 1-Aryltetrahydro-β-carbolines Are Potent Antimalarials In Vitro

[vc_row css_animation="" row_type="row" use_row_as_full_screen_section="no" type="full_width" angled_section="no" text_align="left" background_image_as_pattern="without_pattern"][vc_column width="2/3"][vc_column_text]The tetrahydro-β-carboline scaffold has proven fertile ground for the discovery of antimalarial agents (e.g., MMV008138 (1) and cipargamin (2)). Similarity searching of a publicly disclosed collection of antimalarial hits for molecules resembling 1 drew our attention to N2-acyl tetrahydro-β-carboline...

Read More
Belen Cassera

Malaria Box-Inspired Discovery of N-Aminoalkyl-β-carboline-3-carboxamides, a Novel Orally Active Class of Antimalarials

[vc_row css_animation="" row_type="row" use_row_as_full_screen_section="no" type="full_width" angled_section="no" text_align="left" background_image_as_pattern="without_pattern"][vc_column width="2/3"][vc_column_text]Virtual ligand screening of a publicly available database of antimalarial hits using a pharmacophore derived from antimalarial MMV008138 identified TCMDC-140230, a tetrahydro-β-carboline amide, as worthy of exploration. All four stereoisomers of this structure were synthesized, but none...

Read More
Roberto Docampo, a leading researcher in the study of acidocalcisomes in trypanosomatids

New insights into the role of acidocalcisomes in trypanosomatids

[vc_row css_animation="" row_type="row" use_row_as_full_screen_section="no" type="full_width" angled_section="no" text_align="left" background_image_as_pattern="without_pattern"][vc_column width="2/3"][vc_column_text]Acidocalcisomes are electron-dense organelles rich in polyphosphate and inorganic and organic cations that are acidified by proton pumps, and possess several channels, pumps and transporters. They are present in bacteria and eukaryotes and have been studied in...

Read More

Activity-based Crosslinking to Identify Substrates of Thioredoxin-domain Proteinsin Malaria Parasites

[vc_row css_animation="" row_type="row" use_row_as_full_screen_section="no" type="full_width" angled_section="no" text_align="left" background_image_as_pattern="without_pattern"][vc_column width="2/3"][vc_column_text]Malaria remains a major public health issue, infecting nearly 220 million people every year. The spread of drug-resistant strains of Plasmodium falciparum around the world threatens the progress made against this disease. Therefore, identifying druggable and essential pathways in P....

Read More
Ronald Drew Etheridge

Protozoan phagotrophy from predators to parasites: An overview of the enigmatic cytostome-cytopharynx complex of Trypanosoma cruzi

[vc_row css_animation="" row_type="row" use_row_as_full_screen_section="no" type="full_width" angled_section="no" text_align="left" background_image_as_pattern="without_pattern"][vc_column width="2/3"][vc_column_text]Eating is fundamental and from this basic principle, living organisms have evolved innumerable strategies to capture energy and nutrients from their environment. As part of the world's aquatic ecosystems, the expansive family of heterotrophic protozoans uses self-generated...

Read More

The good, the bad, and the ugly: From planarians to parasites

[vc_row css_animation="" row_type="row" use_row_as_full_screen_section="no" type="full_width" angled_section="no" text_align="left" background_image_as_pattern="without_pattern"][vc_column width="2/3"][vc_column_text]Platyhelminthes can perhaps rightly be described as a phylum of the good, the bad, and the ugly: remarkable free-living worms that colonize land, river, and sea, which are often rife with color and can display extraordinary regenerative...

Read More

Trainee Spotlight: Justine Shiau

[vc_row css_animation="" row_type="row" use_row_as_full_screen_section="no" type="full_width" angled_section="no" text_align="left" background_image_as_pattern="without_pattern"][vc_column width="2/3"][vc_column_text] Justine Shiau, an NIH T32 fellow in Dr. Dennis Kyle's laboratory, is originally from Taipei, Taiwan, and moved to the states after elementary school. She received her bachelor's degree in Biology from the Pennsylvania State University, where...

Read More
Cassiopeia Russell

Differential Growth Rates and In Vitro Drug Susceptibility to Currently Used Drugs for Multiple Isolates of Naegleria fowleri

[vc_row css_animation="" row_type="row" use_row_as_full_screen_section="no" type="full_width" angled_section="no" text_align="left" background_image_as_pattern="without_pattern"][vc_column width="2/3"][vc_column_text]The free-living amoeba Naegleria fowleri, which typically dwells within warm, freshwater environments, can opportunistically cause primary amoebic meningoencephalitis (PAM), a disease with a mortality rate of >97%. The lack of positive treatment outcomes for PAM has prompted...

Read More
Strand and Brown

Insulin-like peptide 3 stimulates hemocytes to proliferate in anautogenous and facultatively autogenous mosquitoes

[vc_row css_animation="" row_type="row" use_row_as_full_screen_section="no" type="full_width" angled_section="no" text_align="left" background_image_as_pattern="without_pattern"][vc_column width="2/3"][vc_column_text]Most mosquito species are anautogenous, which means they must blood feed on a vertebrate host to produce eggs, while a few are autogenous and can produce eggs without blood feeding. Egg formation is best understood in the...

Read More
Vasant Muralidharan

Vasant Muralidharan interviewed on The Athens Frontline Podcast

[vc_row css_animation="" row_type="row" use_row_as_full_screen_section="no" type="full_width" angled_section="no" text_align="left" background_image_as_pattern="without_pattern"][vc_column width="2/3"][vc_column_text] Vasant Muralidharan, associate professor of cellular biology and a member of CTEGD, was recently interviewed for The Athens Frontline podcast episode The Next Pandemic. Listen as he discusses mRNA technology, the pandemic, and other emerging diseases.[/vc_column_text][vc_empty_space][vc_raw_html]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[/vc_raw_html][/vc_column][vc_column width="1/3"][vc_widget_sidebar...

Read More