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Tag: Trypanosoma cruzi

Membrane contact activation of Piezo2 drives lysosome-mitochondrion Ca2+ transfer and signaling in Trypanosoma cruzi

Donna Huber on October 20, 2026

  Calcium ion (Ca2+) transfer from other organelles is central to mitochondrial metabolism and cell survival, yet how mechanical forces regulate interorganelle communication remains unclear. Here we report a lysosome-to-mitochondrion pathway in Trypanosoma cruzi, the etiologic agent of Chagas disease, mediated by the mechano/osmosensitive channel TcPiezo2. Using ultrastructural, biochemical, and live-cell superresolution imaging, we define …

BDF6 Deficiency Severely Compromises Intracellular Amastigote Development and Infectivity of Trypanosoma cruzi

Donna Huber on October 9, 2026

Trypanosoma cruzi, the causative agent of Chagas disease, relies on complex gene regulatory mechanisms to adapt to its diverse host environments. In recent years, it has been established that epigenetics plays an essential role in these mechanisms via the regulation of chromatin structure. Bromodomain-containing factors (BDFs), known for recognizing acetylated lysines on histones, have emerged …

A global S-palmitoylation map of Trypanosoma cruzi identifies ABCA10 as a key component of a redundant heme-acquisition system

Donna Huber on September 24, 2026

  Survival and transmission of the human pathogen Trypanosoma cruzi depend on dynamic remodeling of its membrane proteome, yet the post-translational networks governing this plasticity remain obscure. Using metabolic labeling and quantitative mass spectrometry, we present a comprehensive map of the T. cruzi S-palmitoylome: a high-confidence atlas of 254 proteins enriched for signaling factors, cytoskeletal …

Glycocalyx-Driven Immunomodulation in Trypanosoma cruzi: Structures, Host Responses, Diagnostic and Therapeutic Targeting

Donna Huber on July 10, 2026

Chagas disease, caused by Trypanosoma cruzi, remains an important neglected infection due to underdiagnosis, global spread resulting from increased migration of people infected with T. cruzi and concomitant organ transplantation and blood transfusion, and limited availability of chemotherapy. The parasite’s surface is covered by a dense glycocalyx enriched in GPI-anchored mucins, trans-sialidases, and glycoinositolphospholipids (GIPLs), …

Glycosomal Phosphoenolpyruvate Carboxykinase CRISPR/Cas9-Deletion and Its Role in Trypanosoma cruzi Metacyclogenesis and Infectivity in Mammalian Host

Donna Huber on March 12, 2026

Trypanosoma cruzi, the causative agent of Chagas disease, possesses glycosomes-unique organelles that house key metabolic enzymes, several of which are promising therapeutic targets. Among them, phosphoenolpyruvate carboxykinase (PEPCK) plays a central role in succinic fermentation, the main pathway for NAD+ regeneration within the organelle. Using CRISPR/Cas9 editing, the PEPCK gene was disrupted in T. cruzi, …

Selenocyanate-Containing Molecules as Trypanosoma cruzi Inhibitors: Impact of Regioisomerism, Conformational Restriction, and Second-Ring Substitution

Donna Huber on November 11, 2025

As a continuation of the project aimed at searching for new chemotherapeuticagents against Chagas disease or American trypanosomiasis, new selenocyanate derivatives are designed, synthesized, and biologically evaluated against the clinically more relevant dividing amastigote form of Trypanosoma cruzi, the etiologic agent of this illness. Furthermore, as all the title compounds are fluorine-containing molecules, it seemed …

UGA researchers develop first test of cure for Chagas disease

Donna Huber on July 1, 2025

New test protocol can detect low levels of Trypanosoma cruzi, the parasite that causes Chagas disease Researchers at the University of Georgia’s Center for Tropical and Emerging Global Diseases have developed the first test to determine whether treatment for Chagas disease was effective. An estimated 6 million to 8 million people worldwide are infected with …

In the News: Rick Tarleton

Donna Huber on June 24, 2025

UGA researchers develop first test of cure for Chagas disease (UGA Today) UGA Pioneers First Test for Chagas Disease Cure (Mirage) UGA researchers develop first test of cure for Chagas disease (Newswise) ¿Se curó la infección de Chagas? Un nuevo test podría dar la respuesta (Infobae) Chagas disease: Test for cure (Outbreak News Today) AN2 …