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Tag: Schistosomiasis

Test, Treat, Track, Test, and Treat Active Surveillance toward Elimination of Schistosomiasis: A Feasibility Study

Donna Huber on July 13, 2020

We assessed the feasibility of using a test, treat, track, test, and treat (5T) active surveillance strategy to identify and treat individuals with schistosomiasis in three very low-prevalence villages in Kafr El Sheikh Governorate, Egypt. Primary index cases (PICs) were identified using the point-of-care circulating cathodic antigen (POC-CCA) assay in schools, in rural health units …

SCORE – a decade of operational research with a lasting legacy

Donna Huber on July 10, 2020

It all began with a simple phone call and now, more than a decade later, the Schistosomiasis Consortium for Operational Control and Evaluation (SCORE) is preparing to pass the baton to new groups of investigators working on understanding and controlling schistosomiasis. Under the direction of Dan Colley, a member of the Center for Tropical and …

Evaluation of Morbidity in Schistosoma Mansoni-Positive Primary and Secondary School Children After Four Years of Mass Drug Administration of Praziquantel in Western Kenya

Donna Huber on June 15, 2020

Background: World Health Organization guidelines recommend preventive chemotherapy with praziquantel to control morbidity due to schistosomiasis. The primary aim of this cross-sectional study was to determine if 4 years of annual mass drug administration (MDA) in primary and secondary schools lowered potential markers of morbidity in infected children 1 year after the final MDA compared to …

Nationwide Remapping of Schistosoma mansoni Infection in Rwanda Using Circulating Cathodic Antigen Rapid Test: Taking Steps Toward Elimination

Donna Huber on May 18, 2020

Eugene Ruberanziza, Udo Wittmann, Aimable Mbituyumuremyi, Alphonse Mutabazi, Carl H. Campbell Jr, Daniel G. Colley, Fiona M. Fleming, Giuseppina Ortu, Govert J. van Dam, Irenee Umulisa, Jamie Tallant, Michee Kabera, Muhammed Semakula, Paul L. A. M. Corstjens, Tharcisse Munyaneza, Warren Lancaster, Jean Bosco Mbonigaba and Michelle N. Clements. Am J Trop Med Hyg. 2020 May 18. doi: 10.4269/ajtmh.19-0866.

Supplemental Articles: Operational Research on Controlling and Eliminating Schistosomiasis (SCORE)

Donna Huber on May 12, 2020

These articles are available online ahead of print and summarize much of the work of the Schistosomiasis Consortium for Operational Research and Evaluation (SCORE). The articles will be published as a supplement to the July issue of The American Journal of Tropical Medicine and Hygiene. Schistosomiasis Consortium for Operational Research and Evaluation: Mission Accomplished The …

Global Schistosomiasis Alliance pays tribute to Dan Colley

Donna Huber on April 28, 2020

Dan Colley in his lab at UGA (photo credit: Andrew Tucker)   Dr. Daniel G. Colley, Director of the Schistosomiasis Consortium for Operational Research and Evaluation (SCORE), will be retiring from his position as Professor at the University of Georgia on June 30, 2020. He will continue as a Professor Emeritus. The Global Schistosomiasis Alliance …

Survey of Schistosomiasis in Saint Lucia: Evidence for Interruption of Transmission

Donna Huber on February 10, 2020

Saint Lucia at one time had levels of schistosomiasis prevalence and morbidity as high as many countries in Africa. However, as a result of control efforts and economic development, including more widespread access to sanitation and safe water, schistosomiasis on the island has practically disappeared. To evaluate the current status of schistosomiasis in Saint Lucia, …

Environmental Predictors of Schistosomiasis Persistent Hotspots following Mass Treatment with Praziquantel

Donna Huber on December 30, 2019

Schistosomiasis control programs rely heavily on mass drug administration (MDA) campaigns with praziquantel for preventative chemotherapy. Areas where the prevalence and/or intensity of schistosomiasis infection remains high even after several rounds of treatment, termed “persistent hotspots” (PHSs), have been identified in trials of MDA effectiveness conducted by the Schistosomiasis Consortium for Operational Research and Evaluation …

Modeling approaches to predicting persistent hotspots in SCORE studies for gaining control of schistosomiasis mansoni in Kenya and Tanzania

Donna Huber on October 17, 2019

BACKGROUND: Some villages, labeled "persistent hotspots (PHS)," fail to respond adequately in regard to prevalence and intensity of infection to mass drug administration (MDA) for schistosomiasis. Early identification of PHS, for example, before initiating or after a year or two of MDA could help guide programmatic decision-making. METHODS: In a study with multiple rounds of …