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Author: Donna Huber

Trainee Spotlight: Josh Butler

New T32 trainee Josh Butler is a third year Ph.D. student in Belen Cassera‘s laboratory. He is from Front Royal, Virginia and completed his B.S. in chemistry at James Madison University in Harrisonburg, Virginia. Butler decided to pursue his graduate degree at the University of Georgia because of the Integrate Life Sciences program which offers …

The Mitochondrial Ca2+ Uniporter Complex (MCUC) of Trypanosoma brucei Is a Hetero-oligomer That Contains Novel Subunits Essential for Ca2+ Uptake

ABSTRACT The mitochondrial calcium uniporter complex (MCUC) is a highly selective channel that conducts calcium ions across the organelle inner membrane. We previously characterized Trypanosoma brucei’s MCU (TbMCU) as an essential component of the MCUC required for parasite viability and infectivity. In this study, we characterize its paralog T. brucei MCUb (TbMCUb) and report the identification of two …

CRISPR/Cas9 Gene Editing to Make Conditional Mutants of Human Malaria Parasite P. falciparum

ABSTRACT Malaria is a significant cause of morbidity and mortality worldwide. This disease, which primarily affects those living in tropical and subtropical regions, is caused by infection with Plasmodium parasites. The development of more effective drugs to combat malaria can be accelerated by improving our understanding of the biology of this complex parasite. Genetic manipulation of these …

Steve Hajduk to give keynote address at Molecular Parasitology Meeting

Dr. Stephen Hajduk is an Emeritus Professor at the University of Georgia, USA. He has had a long and distinguished career making significant contributions to our understanding of the underlying mechanisms and function of gene expression, RNA editing, human innate immunity to trypanosome infection and the role of membrane nanotubes and extracellular vesicles (EVs) in communication …

CTEGD opens lab doors to undergraduates at area schools

by Donna Huber When UGA alumna Dr. Sharon Keller accepted the position of Assistant Professor at Georgia Gwinnett College (GGC) she wasn’t ready to say goodbye to the research project she started in graduate school. Since GGC is not a research-intensive institution, Keller approached her Ph.D. mentor Dr. Silvia Moreno, distinguished research professor in the …

Young Adults in Endemic Areas: An Untreated Group in Need of School-Based Preventive Chemotherapy for Schistosomiasis Control and Elimination

Abstract Parasitologic surveys of young adults in college and university settings are not commonly done, even in areas known to be endemic for schistosomiasis and soil-transmitted helminths. We have done a survey of 291 students and staff at the Kisumu National Polytechnic in Kisumu, Kenya, using the stool microscopy Kato-Katz (KK) method and the urine …

Antiplasmodial flavanones and a stilbene from Carpha glomerata

  Abstract Bioassay-guided fractionation of an extract of Carpha glomerata (Cyperaceae) led to the isolation of seven compounds. Compounds 1 (carphorin A), 3 (carphorin C), 4(carphorin D), and 5 (carphabene) are new compounds, and compound 2 (8-(3″-hydroxyisoamyl)-naringenin) was isolated for the first time as a natural product. All structures were elucidated based on analyses of their HR-ESIMS and 1D and 2D NMR data. Compounds 1, 2, and 6, which …

Spatio-temporal spillover risk of yellow fever in Brazil

Abstract Background: Yellow fever virus is a mosquito-borne flavivirus that persists in an enzoonotic cycle in non-human primates (NHPs) in Brazil, causing disease in humans through spillover events. Yellow fever (YF) re-emerged in the early 2000s, spreading from the Amazon River basin towards the previously considered low-risk, southeastern region of the country. Previous methods mapping …