Samarchith Kurup

Training

2013 Ph.D., Department of Cellular Biology, University of Georgia, Athens, GA, USA
2008 MVSc., Indian Veterinary Research Institute, UP, India
2006 DVM Kerala Agricultural University, Kerala, India

Research

Research in the Kurup lab is focused on understanding the mechanism of natural and acquired immunity to liver-stage malaria. We investigate the cellular and molecular pathways that help detect Plasmodium in the infected hepatocytes and help drive immunity to the parasite.

Selected Publications

1. Kurup SP, Butler NS, Harty JT., T cell-mediated immunity to malaria. Nat Rev Immunol. 2019 Apr 2. doi: 10.1038/s41577-019-0158-z. [Epub ahead of print] Review.
2. Kurup SP, Anthony SM, Hancox LS, Vijay R, Pewe LL, Moioffer SJ, Sompallae R, Janse CJ, Khan SM, Harty JT., Monocyte-Derived CD11c+ Cells Acquire Plasmodium from Hepatocytes to Prime CD8 T Cell Immunity to Liver-Stage Malaria. Cell Host Microbe. Mar 13. pii: S1931-3128(19)30110-6. doi: 10.1016/j.chom.2019.02.014.
3. Kurup SP, Obeng-Adjei N, Anthony SM, Traore B, Doumbo OK, Butler NS, Crompton PD, Harty JT., Regulatory T cells impede acute and long-term immunity to blood-stage malaria through CTLA-4, Nat Medicine; 23(10):1220-1225 (2017) (Cover story) PMCID: PMC556421
4. Kurup SP, Tarleton RL, The Trypanosoma cruzi flagellum is discarded via asymmetric division following invasion and provides early targets for protective CD8+ T cells. Cell Host Microbe 16(4):439-49 (2014) PMCID: PMC4194031.
5. Kurup SP, Tarleton RL, Perpetual expression of PAMPs necessary for optimal control and clearance of a persistent pathogen. Nat commun 4:2616 (2013) PMCID: PMC4161029.

News

All the pieces matter: UGA researchers collaborate to solve malaria puzzle

UGA researcher uncovers humans’ natural weapon against malaria