Praziquantel target validation of a Ca2+ permeable channel in schistosomes
- Schistosomiasis is a devastating neglected helminthic disease.
- Praziquantel (PZQ) is the most important drug against schistosomiasis.
- Previous work identified a TRP channel of the melastatin type as a PZQ target.
- Molecular studies now reveal the basis for varied PZQ sensitivity of different helminths.
Roberto Docampo. Cell Calcium. 2023 Jan 18;110:102698. doi: 10.1016/j.ceca.2023.102698