O2 sensing associated glycosylation exposes the F-box combining site of the Dictyostelium Skp1 subunit in E3 ubiquitin ligases
Sheikh MO, Thieker D, Chalmers G, Shafer CM, Ishihara M, Azadi P, Woods RJ, Glushka JN, Bendiak B, Prestegard JH, West CM. J Biol Chem. 2017 Sep 19. doi: 10.1074/jbc.M117.809160 [Epub ahead of print]
Trainee Spotlight: Evgeniy Potapenko
Evgeniy’s research focus
Generally, Evgeniy is interested in mechanisms of transmembrane transport and their role in parasite homeostasis. His current project goal is to characterize how the IP3R function modulated within the Trypanosoma brucei, the parasite that causes African Sleeping Sickness, acidocalcisomes where it resides and how deregulation of this process can contribute to cell death. This research topic addresses poorly studied mechanisms of parasite physiology and has the potential importance of discovering new methods of patient treatment.
Capstone Experience
Each T32 trainee is provided with the opportunity to complete a capstone experience at the end of their fellowship. This experience often involves an extended visit to a collaborator’s laboratory to learn new techniques or to an endemic country to see how their research connects to actions being taken in the field.
“I hope to expand my expertise in both electrophysiology and cellular biology approaches, which will allow me to conduct independent research,” said Evgeniy.
T32 fellowship helps trainee achieve goals
“T32 is a unique possibility to prepare me for an independent research career,” said Evgeniy. “It gives great tools to achieve this goal.”
Dynamic nuclear polarization facilitates monitoring of pyruvate metabolism in trypanosoma brucei
Zhuo Y, Cordeiro CD, Hekmatyar SK, Docampo R, Prestegard JH. J Biol Chem. 2017 Sep 8. doi: 10.1074/jbc.M117.807495. [Epub ahead of print]